Italy: I'm fine with Rome. As some rumors, here and there, have it, a major car chase may be the center piece and in Rome (having driven there myself long ago) that can be dicey even when not being chased or chasing someone about.
As to other locales. I've got three I've been all for going back for almost twenty years.
Australia is certainly one of them. Sydney has a lot to offer, but Perth is also a great major port. Either has plenty to offer and one of the major locales. MI:2 made good use of Sydney. At one point, back in the early days of what would become our beloved CBn, there were notions that DAD would be shot there and that it was always considered for some part of TWINE. After MI:2, there wasn't anymore talk.
Lisbon: Still the hot-bed of real world espionage today as it was in both WWII and the Cold War. If you're looking for a lot of various ex-pat intelligence officers, that's where to find them. Also a very stylish city.
Hawaii: Bond hasn't been there yet either. Go with either Hawaii, Maui, Molokai or Kauai. All have much to offer. I've got a list of ideas for Maui (one of my personal favorite escapes when I can). If anyone needs ideas for a vacation, let me know.
As an extra, my home town: Seattle. Lovely place, Space Needle and some major business, tech and military - i.e. Microsoft, Amazon, Boeing and the worldwide coffee chain. Also, the Trident submarine base in Bangor.
BOT though - Do we know anything else at present about Rome or Italy? Naples is lovely too.