Some actors I think would be good Bond villains are Steve Buscemi, Kelsey Grammer, Christopher Lloyd, Elias Koteas, Vincent D'Onofrio, John Stamos, and Topher Grace. Some are more likely than others, but all are good actors.
You are joking, right? Topher Grace couldn't menace the Rugrats. Kelsey Grammar has a cool voice. John Stamos has pretty hair and can play the drums. The only way they should be part of a Bond movie is if they pay for a ticket first.