It would be really good for them to cast a strong, intelligent female character over 40. It also deflects a lot of the traditional criticism of the Bond series. While they usually go for relative unknowns for the female lead, I can see this casting as an important character who clicks and resonates with Bond's.
A casting like that might have saved TWINE's horrendous Christmas Jones character, added some experience and depth to Holly in Moonraker, completely salvaged the Stacey Sutton character in A View to a Kill, or made for better chemistry with Paris Carver and Bond than Terri Hatcher did.