Daniel Craig reveals 'Bond 22' plot details
Back in 2006 before Casino Royale even premiered, Craig mentioned that the organization behind Le Chiffre wanted to "destabilise the world with money." Now, in an interview with Rotten Tomatoes, Craig revealed that the villains of Bond 22 are planning to "destabilise the world's economy because they want to take it over." He also mentions there is no title yet and that there is a connection between Vesper and Mathieu Amalric's character.
My educated guess is an attack on the Panama Canal, which would cripple the Atlantic/Pacific trade route and probably relaunch ownership tensions over the Neutral Zone. We already know they're filming in Colon province and capital, both of which lay on the canal route. Any other ideas?