No Q because of QUANTUM, instead Major Boothroyd. But...I'd really love to see Dan at some point to visit Q's lab. Even Dan said he was looking forward to it.
As for Miss Moneypenny....I hope they make the relationship more like Sean and Lois apposed to any of the other actors's relationship with thiers. There was just somethign about those two on the screen, but I guess Sean was the easiest Bond to fall in love with a bit.
As for her casting...
Keeley Hawes
She's exactly who I had in mind.