I think with all the recent suggestions (the rally chase idea, Bond tracking down Honey, the South African location) it might be helpful to have some sort of bare bones bullet point outline to move forward. Could dino or terminus possibly work something up?
Here are some things I put together so far, terminus and others are welcome to add to it.
PTS - TBD, set in Jamaica
Post-credits scene : Strangways, a junior MI6 Agent, is breaking into an office building in Cape Town, South Africa. He accesses a computer and clicks through various files on accounts and records of an abalone fishing business. One file on the screen catches his attention : "DOCTOR NO". (I thought this would be a nice modern nod to the original's use of the "DOCTOR NO" file folder). Before he can click on it, two assassins burst into the room and a shootout ensues. Strangways flees and almost escapes, but a third assassin is waiting for him outside and knocks him out.
MI6 - Bond is frustrated with the lack of progress in pursuing leads on QUANTUM. All information obtained from Yusuf turned out to be mostly useless. Key QUANTUM members have turned up dead, bank accounts have been emptied, it appears as if the organization has gone into hiding. M orders Bond to investigate the death of Strangways, whose corpse recently washed up on a beach outside of Cape Town, looking like he was mauled by some kind of sea creature. "I've always fancied a trip to South Africa", remarks Bond (wink, wink at the dialogue).
Cape Town, South Africa - We need to flesh out this section of the film. Bond should come into contact with DENT, the head of the legitimate abalone business, and will soon discover that Dent is using illegal poaching methods to procure the specimens. The trail will lead him to a mysterious figure known as QUARREL, whom Bond will surprisingly discover to be a woman. Quarrel tries to shake down Bond in a bar, with the help of a Pussfeller-esque brute, but is helped out by none other than Felix Leiter, taking a break from his duties as the CIA's station head of South America.
-The three assassins will target Bond, leading to a car chase in a desert.
-The spider/centipede scene should be recreated somehow.
-Dent will try to assassinate Bond himself, leading to a brutal fight between the two men in Bond's hotel room.
-Bond will encounter Honey Ryder, nude, on a beach! Honey is running a more legal abalone operation, and she explains that abalone have been turning up dead washed up on the shore. Bond finds traces of radiation in the abalone, and together with Quarrel, they target Bouvet Island as a possible source of the contamination. Quarrel is terrified of a 'dragon' that is said to live on the island, but Bond persuades her to go anyway.
-I figured that from that point, we'd essentially follow the original film, with Quarrel being killed, Bond and Honey being caught and having dinner with Dr. No (perhaps with Mr.White as the fourth guest at the table!). No would then put Bond through his deadly pipes challenge, ending in Craig rolling around with a giant squid!
-Final confrontation with Dr.No as the island blows up all around them due to Bond destroying Dr.No's operation.